Panacur bolus is a cylindrical intraruminal device consisting of 10 grey/black flat-faced intraruminal devices in a magnesium alloy tube enclosed by plastic rings.
Each intraruminal device contains 12 grams fenbendazole. Each intraruminal device is of sufficient weight to ensure that it remains in the reticulorumen.
Panacur cattle bolus is used for the treatment and prophylactic control of all economically important gastrointestinal roundworm infections in cattle weighing between 100 and 300 kg at the time of administration. Also as an aid in control of parasitic bronchitis (lungworm infection). Activity Gastrointestinal roundworms (Gut worms) The Panacur Bolus is designed to release fenbendazole continuously in the reticulo-rumen of cattle for up to 140 days (20 weeks). The Panacur Bolus treats and controls parasitic disease caused by the following gut roundworms: Ostertagia spp. Trichostrongylus spp. Oesophagostomum spp. Cooperia spp. Haemonchus spp. When administered at turnout the intraruminal device controls parasitic gastroenteritis throughout the grazing season by reducing the build-up of infective larvae on the pasture. Reduced pasture contamination in the Autumn lowers the risk of inhibited Ostertagia larvae accumulating in the abomasum in sufficient numbers to cause winter ostertagiasis. When administered later in the season the intraruminal device treats established parasitic infections and continues to control parasitic gastroenteritis up to 140 days after administration. This period may be reduced if cattle are moved to heavily infected pasture. Lungworm The Panacur Bolus aids in the control of parasitic bronchitis caused by the lungworm Dictyocaulus viviparus.
Dosage and administration
To ensure administration of a correct dose body weight should be determined as accurately as possible; accuracy of the dosing device should be checked. Administer the intraruminal device gently and with great care. One intraruminal device to be administered orally to each animal before being turned out to grass. Alternatively animals which have already been turned out can be administered an intraruminal device later in the grazing season. All animals within a group grazing the same pasture must be treated with a Panacur Bolus to ensure maximum benefits from the system. All newcomers to the group must also be administered a Panacur Bolus before being turned out to grass. Administration is achieved using the Panacur Bolus Applicator which helps to administer the intraruminal device directly into the top of the oesophagus. Insert an intraruminal device into the applicator. Restrain the animal and extend the head forward keeping the neck straight. Insert the applicator into the front of the mouth and firmly but gently push it over the back of the tongue. Keeping the neck straight tilt the head upwards and the animal will begin to swallow the end of the applicator - indicated by easier passage of the applicator down the throat. The intraruminal device can then be ejected into the oesophagus by squeezing the release trigger on the applicator. Do not use force when administering the intraruminal device. Observe the animal for a short time to ensure the intraruminal device has been swallowed. As the metal of the intraruminal device can be detected the correct position of the intraruminal device can be checked by a suitable metal detector
Contra-indications warnings etc
Do not use in pre-ruminating cattle cattle weighing less than 100 kg or cattle less than 3 months of age. Do not administer to cattle over 300 kg. If lungworm vaccination is practised in cattle before turnout the intraruminal device should not be administered until 14 days after the second dose of vaccine has been given. Ensure all animals weigh more that 100 kg/bw. Do not administer concurrently with other medicinal intraruminal devices. If an intraruminal device-treated animal is sold during the season the purchaser must be informed of the date on which the intraruminal device was administered. The intraruminal device can interfere with the detection of foreign bodies (hardware disease) by an electronic metal detector. Immunity to nematodes depends on adequate exposure to infection. Although not normally the case circumstances could occur in which anthelmintic control measures might increase the vulnerability of cattle to re-infection. Animals may be at risk towards the end of their first grazing season particularly if the season is long or in the following year if they are moved onto heavily contaminated pasture. In such circumstances further control measures may be necessary. Where specific preventative control of lungworm is required it is advised that cattle are given an appropriate lungworm vaccine. As the product allows a small percentage of lungworm to reach the lungs when cattle are exposed it will not interfere with the development of immunity. Under conditions of heavy larval challenge clinical signs of lungworm may become evident. Therefore if clinical signs of lungworm occur in treated cattle they should be dosed immediately with an appropriate anthelmintic. Without additional control measures such as vaccination lungworm infestations can sometimes occur during the life of the intraruminal device. General warnings Intensive use or misuse of anthelmintics can give rise to resistance. To reduce this risk dosing programmes should be discussed with veterinary surgeon. Care should be taken to avoid the following practices because they increase the risk of development of resistance and could ultimately result in ineffective therapy: - Too frequent and repeated use of anthelmintics from the same class over an extended period of time. - Underdosing which may be due to underestimation of body weight misadministration of the product or lack of calibration of the dosing device (if any). Suspected clinical cases of resistance to anthelmintics should be further investigated using appropriate tests (e.g. Faecal Egg Count Reduction Test). Where the results of the test(s) strongly suggest resistance to a particular anthelmintic an anthelmintic belonging to another pharmacological class and having a different mode of action should be used. Resistance to benzimidazoles has been reported in Teladorsagia Haemonchus Cooperia and Trichostrongylus species in small ruminants. Therefore the use of this product should be based on local (regional farm) epidemiological information about susceptibility of nematodes and recommendations on how to limit further selection for resistance to anthelmintics. The product has been used successfully and without undesirable effects in pregnant cows but is not intended for use in this class of animal. The product has not been evaluated for compatibility with other medicinal intraruminal devices yet and therefore use with other medicinal intraruminal devices is not recommended. Operator warnings Wash hands after use. Direct contact with the skin should be kept to a minimum. Withdrawal periods Animals must not be slaughtered for human consumption during treatment. Cattle may be slaughtered for human consumption only after 200 days from administration of the intraruminal device. Not for use in cattle producing milk for human consumption or to dairy heifers within 200 days of parturition. For animal treatment only. Keep out of reach and sight of children.