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RCVS Registered: 7025700
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Frontline Combo Spot On x 6 Pipettes for Large Dogs 20-40kg
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Frontline Combo Spot On x 6 Pipettes for Large Dogs 20-40kg



Frontline Combo is used against infestations with fleas ticks and/or biting lice. VET PRESCRIPTION REQUIRED

Product Features

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  • Pack Size: - 6 Pipettes
  • Target Animal: - Dog (Canine)
  • Pet Prescription Required?: - Yes (For UK Orders)
  • Active Ingredient: - Fipronil and (S)-methoprene
  • Product Name: - Frontline Combo Spot On x 6 Pipettes for Large Dogs 20-40kg

More Information

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This medication may only be supplied with a valid veterinary prescription issued by your vet. You should only purchase this item if you have or are in the process of arranging such a prescription. See information bar for further details.

Frontline Combo is a Spot-on solution. Small: 1 pipette of 0.67 ml contains fipronil 67 mg (S)-methoprene 60.30 mg. Medium: 1 pipette of 1.34 ml contains fipronil 134 mg (S)-methoprene 120.60 mg. Large: 1 pipette of 2.68 ml contains fipronil 268 mg (S)-methoprene 241.20 mg. XL: 1 pipette of 4.02 ml contains fipronil 402 mg (S)-methoprene 361.80 mg. Also contains butylhydroxyanisole (E320) and butylhydroxytoluene (E321).

Frontline Combo is to be used against infestations with fleas ticks and/or biting lice. - Elimination of fleas (Ctenocephalides spp.) and insecticidal efficacy against new infestations with adult fleas persists for 8 weeks. - Prevention of the multiplication of fleas by inhibiting the development of eggs (ovicidal activity) and larvae and pupae (larvicidal activity) originating from eggs laid by adult fleas for 8 weeks after application. - Elimination of ticks (Ixodes ricinus Dermacentor variabilis Rhipicephalus sanguineus). The product has persistent acaricidal efficacy for up to 4 weeks against ticks. - Elimination of biting lice (Trichodectes canis). The product can be used as part of a treatment strategy for the control of Flea Allergy Dermatitis (FAD).

Dosage and administration
Frontline Combo Dosage 1 pipette of 0.67 ml (S) per dog weighing over 2 and up to 10 kg; 1 pipette of 1.34 ml (M) per dog weighing over 10 kg and up to 20 kg; 1 pipette of 2.68 ml (L) per dog weighing over 20 kg and up to 40 kg; 1 pipette of 4.02 ml (XL) per dog weighing over 40 kg; corresponding to a minimum recommended dose of 6.7 mg/kg for fipronil and 6 mg/kg for (S)-methoprene by topical application to the skin. In the absence of safety studies the minimum treatment interval is 4 weeks. Method of administration Hold the pipette upright. Tap the narrow part of the pipette to ensure the contents remain within the main body of the pipette. Snap back the tip. Part the coat on the back of the animal at the base of the neck in front of the shoulder blades until the skin is visible. Place the tip of the pipette on the skin and squeeze the pipette several times to empty its contents completely and directly onto the skin in one spot.  

Contra-indications warnings etc
For animal treatment only. In the absence of available data the product should not be used on puppies less than 8 weeks old and/or weighing less than 2 kg. No adverse effects were observed in target animal safety studies in 8 week-old puppies growing dogs and dogs weighing about 2 kg treated once at five times the recommended dose. The risk of experiencing adverse effects may however increase when overdosing so animals should always be treated with the correct pipette size according to bodyweight. The product can be used during pregnancy and lactation. Do not use on sick (systemic diseases fever�) or convalescent animals. Do not use in rabbits as adverse reactions and even death could occur. This product is specifically developed for dogs. Do not use in cats as this could lead to overdosing. Do not overdose. It is important to make sure that the product is applied to an area where the animal cannot lick it off and to make sure that animals do not lick each other following treatment. If licking occurs a brief period of hypersalivation may be observed due mainly to the nature of the carrier. Bathing/immersion in water within 2 days after application of the product and more frequent bathing than once a week should be avoided as no study has been performed to investigate how this affects the efficacy of the product. Emollient shampoos can be used prior to treatment but reduce the duration of protection against fleas to approximately 5 weeks when used weekly after application of the product. Weekly bathing with a 2% chlorhexidine medicated shampoo did not affect efficacy against fleas during a 6 week long study. Dogs should not be allowed to swim in watercourses for 2 days after application. There may be an attachment of single ticks. For this reason transmission of infectious diseases cannot be completely excluded if conditions are unfavourable. Fleas from pets often infest the animal`s basket bedding and regular resting areas such as carpets and soft furnishings which should be treated in case of massive infestation and at the beginning of the control measures with a suitable insecticide and vacuumed regularly. There are no known interactions with other medications. Among the very rare suspected adverse reactions transient skin reactions at the application site (skin discolouration local hair loss itching redness) and general itching or hair loss have been reported after use. Excessive salivation reversible neurological signs (increased sensitivity to stimulation depression other nervous signs) vomiting or respiratory signs have also been observed after use. Avoid contact with the animal`s eyes. Animals with a known hypersensitivity to insecticides or alcohol should avoid contact with FRONTLINE Combo Spot-On Dog.7

Operator safety: Operators with a known hypersensitivity to insecticides or alcohol should avoid contact with FRONTLINE Combo Spot-On Dog. This product can cause mucous membrane skin and eye irritation. Therefore contact of the product with mouth skin and eyes should be avoided. After accidental ocular exposure the eye should be rinsed carefully with pure water. Avoid contents coming into contact with the fingers. If this occurs wash hands with soap and water. Treated animals should not be handled until the application site is dry and children should not be allowed to play with treated animals until the application site is dry. It is therefore recommended that animals are not treated during the day but should be treated during the early evening and that recently treated animals are not allowed to sleep with owners especially children. Wash hands after use. Do not smoke drink or eat during application

Legal category
Frontline Combo is a POM-V (Pet Prescription Required)