Vetoryl Capsules

Vetoryl Capsules are a prescription medicine for dogs diagnosed with Cushing's disease, also called canine hyperadrenocorticism. This condition happens when the body produces too much cortisol, a steroid hormone made by the adrenal glands. Cortisol is important because it helps the body respond to stress and supports normal metabolism, blood pressure regulation and immune function, but persistently high levels can place strain on the skin, muscles, immune system, liver and urinary system.

A Veterinary Pet Prescription is required to purchase Vetoryl in the UK (we accept other proof for international orders)

Vetoryl Capsules contain trilostane, an anti-adrenal active ingredient used to help control cortisol production in dogs with pituitary-dependent or adrenal-dependent Cushing's disease. They are intended for dogs that have been examined, tested and prescribed treatment by a veterinary surgeon, so the dose can be matched to their clinical picture. When used as part of a monitored treatment plan, Vetoryl Capsules can help reduce the clinical signs associated with excess cortisol and support a steadier day-to-day routine for affected dogs and their owners.

Cushing's disease in dogs is most often seen in middle-aged and older pets, although any dog showing signs should be assessed by a vet. Many owners first notice that their dog is drinking more, urinating more often, asking for food constantly, panting at rest or developing a rounded, pot-bellied shape. Other signs can include thinning hair, fragile skin, recurrent skin infections, darkened skin, muscle weakness, tiredness, urinary accidents or a change in general behaviour. Some dogs become less willing to exercise, while others seem unsettled overnight because they need to drink or go outside more often. These signs can develop gradually over months, so they are sometimes mistaken for normal ageing or a simple change in routine.

A diagnosis usually involves a physical examination, blood tests, urine tests and endocrine tests such as an ACTH stimulation test or low-dose dexamethasone suppression test. Because similar signs can occur with diabetes mellitus, kidney disease, liver disease or other endocrine disorders, Vetoryl Capsules should only be started once your vet has confirmed that Cushing's disease is the most likely cause and has ruled out other problems that may need different treatment.

Vetoryl Capsules work by reducing the amount of cortisol made in the adrenal cortex. Trilostane acts selectively and reversibly on an enzyme involved in steroid hormone production, known as 3 beta-hydroxysteroid dehydrogenase/isomerase. By inhibiting this enzyme, Vetoryl Capsules help block part of the pathway that leads to cortisol, corticosterone and, to a lesser extent, aldosterone production. The medicine does not remove the pituitary or adrenal cause of the condition, so it is usually used as an ongoing management treatment rather than a one-off cure. The aim is not to remove cortisol completely, because dogs need a healthy amount of cortisol to function, but to bring excessive levels under better control. This is why regular reviews are important; the best dose is the one that controls clinical signs while keeping hormone levels within a safe range. As cortisol levels become better regulated, many dogs begin to drink less, urinate less frequently, pant less heavily and regain a calmer pattern of rest. With appropriate dosing, Vetoryl Capsules can help improve appetite, coat condition, skin health and energy levels over time.

Vetoryl is available in the following strengths: 10mg Vetoryl Capsules, 30mg Vetoryl Capsules, 60mg Vetoryl Capsules & 120mg Vetoryl Capsules

Your veterinary surgeon will decide the correct strength and dose of Vetoryl Capsules for your dog based on body weight, test results, symptoms and response to treatment. Vetoryl is usually given by mouth with food, because food can improve absorption and makes daily dosing easier for many dogs. Capsules should be swallowed whole and should not be opened, divided or crushed. Treatment needs careful monitoring, especially during the early weeks and after any dose change. Your vet may recommend blood biochemistry, electrolytes and ACTH stimulation testing to check whether cortisol control is adequate and to help avoid the opposite problem, hypoadrenocorticism, where cortisol becomes too low. Morning dosing is often preferred because it can make follow-up testing easier to schedule at the correct time after administration. It is also helpful to keep a simple home record of drinking, urination, appetite, panting, weight and energy, as these everyday observations can guide discussions with your vet.

What are Vetoryl Capsules used for in dogs?
Vetoryl Capsules are used to manage Cushing's disease, also known as canine hyperadrenocorticism. They help control excessive cortisol production, which can reduce signs such as increased thirst, frequent urination, hunger, panting, hair thinning and a pot-bellied appearance when used under veterinary supervision.

How do Vetoryl Capsules work?
Vetoryl Capsules contain trilostane, which acts on the adrenal glands. Trilostane reversibly inhibits an enzyme involved in steroid hormone production, helping reduce excess cortisol. The aim is to bring cortisol into a healthier range, not remove it completely, so careful monitoring is essential.

How quickly do Vetoryl Capsules start working?
Some owners notice improvements in thirst, urination or appetite within the first few weeks, but every dog responds differently. Coat changes and muscle strength can take longer to improve. Your vet will use symptoms and follow-up blood tests to judge whether the dose is right.

Should Vetoryl Capsules be given with food?
Vetoryl Capsules are commonly given with food because food can improve absorption and may make dosing easier for your dog. Follow your vet's instructions on timing and frequency. Do not open, split or crush the capsules, as they are designed to be swallowed whole.

What are common signs of Cushing's disease in dogs?
Common signs include excessive thirst, increased urination, a bigger appetite, panting, thinning hair, fragile skin, recurrent skin infections, weight changes and a rounded abdomen. Because these signs can appear gradually and may overlap with other conditions, veterinary testing is needed before treatment starts.

What side effects should I watch for with Vetoryl Capsules?
Contact your vet if your dog has vomiting, diarrhoea, poor appetite, marked tiredness, weakness, shaking, wobbliness or any sudden change in wellbeing. Severe weakness, collapse or repeated vomiting should be treated urgently, as they may suggest cortisol levels are too low or another illness is present.