Zenrelia for Dogs is a prescription-only medication for dogs aged 12 months and older, used to control itching and inflammation associated with allergic and atopic dermatitis. Zenrelia belongs to a class of medication known as Janus kinase (JAK) inhibitors. Zenrelia is administered once daily by mouth and may be given with or without food.
How Zenrelia works
Zenrelia Tablets act by inhibiting Janus kinase enzymes. These enzymes play a key role in the inflammatory and itch-signal pathways. By reducing the activity of these enzymes, Zenrelia interrupts the itch-scratch cycle. That helps to ease itching and allows inflamed skin to begin healing. It is neither a corticosteroid nor an antihistamine, but it addresses itch and inflammation at a molecular level.
When to use Zenrelia
Zenrelia is suitable for dogs showing symptoms of persistent itching and skin irritation caused by allergic or atopic dermatitis. It may b...
Zenrelia for Dogs is a prescription-only medication for dogs aged 12 months and older, used to control itching and inflammation associated with allergic and atopic dermatitis. Zenrelia belongs to a class of medication known as Janus kinase (JAK) inhibitors. Zenrelia is administered once daily by mouth and may be given with or without food.
How Zenrelia works
Zenrelia Tablets act by inhibiting Janus kinase enzymes. These enzymes play a key role in the inflammatory and itch-signal pathways. By reducing the activity of these enzymes, Zenrelia interrupts the itch-scratch cycle. That helps to ease itching and allows inflamed skin to begin healing. It is neither a corticosteroid nor an antihistamine, but it addresses itch and inflammation at a molecular level.
When to use Zenrelia
Zenrelia is suitable for dogs showing symptoms of persistent itching and skin irritation caused by allergic or atopic dermatitis. It may be used:
At the first consultation to provide itch relief
During diagnostic investigations to manage symptoms
As part of a long-term maintenance plan to control chronic skin conditions
It is not appropriate for use in dogs younger than 12 months, dogs with serious or active infections, or dogs intended for breeding, pregnancy or lactation.
Allergic and atopic dermatitis in dogs
Atopic dermatitis (also known as atopy) is a chronic, lifelong allergic skin disorder that affects approximately 10–15 per cent of dogs. Diagnosis usually follows the exclusion of other causes such as parasites, food allergies or contact dermatitis.
Allergic dermatitis may arise from environmental allergens, flea bites, certain foods or contact with irritants. Symptoms commonly include intense itching, redness, hair loss and skin lesions. Flea allergy dermatitis affects around 8 per cent of dogs, while food-related skin allergies may account for approximately 20 per cent of cases.
Dogs with these conditions often suffer ongoing discomfort, disturbed sleep, secondary skin infections and reduced quality of life.
Zenrelia is a huge improvement on previous treatments for the following reasons:
- Once-daily dosing makes administration straightforward from the outset, without the need for dose ramp-up or tapering.
- Rapid itch relief often observed after just one dose, helping dogs return to normal behaviour.
- Consistent dosing schedule supports better owner adherence.
- Comparable safety profile to existing therapies, with minimal rebound itch risk.
- Suitable for concurrent use with flea control, antibiotics, ear cleaners, sedatives or NSAIDs where appropriate.
Zenrelia modulates the immune system and may impact vaccine response. Dogs must be fully vaccinated before starting treatment. Vaccination should be avoided during Zenrelia therapy and for at least 28 days (up to three months) before and after treatment to minimise the risk of fatal vaccine-induced disease or poor immune response.
