Advocate is a spot-on treatment used to control internal and external parasites affecting extra large dogs. One of the active ingredients is absorbed through the skin and travels around the body, treating internal parasites such as worms. VET PRESCRIPTION REQUIRED
Warning: Last items in stock!
Availability date: 2013-06-07
|Target Animal:||Dog (Canine)|
|Related Condition:||Flea and Worm Treatment in Dogs|
|Pet Prescription Required?:||Yes (For UK Orders)|
|Active Ingredient:||Imidacloprid and Moxidectin|
|Product Name:||Advocate Spot On 400 X-Large Dog - 6 Pipettes|
|Pack Size:||6 Pipettes|
Advocate is a spot-on treatment used to control internal and external parasites affecting dogs andcats. One of the active ingredients is absorbed through the skin and travels around the body, treating internal parasites such as worms. A second ingredient transfers across the surface of the body and kills surface-living parasites such as fleas.
This medication may only be supplied with a valid veterinary prescription, issued by your vet. You should only purchase this item if you have or are in the process of arranging such a prescription. See information bar for further details.
Advocate spot-on solution for cats and ferrets is a clear yellow to brownish solution containing 10 % imidacloprid and 1.0 % moxidectin with benzyl alcohol and Butylhydroxytoluene 1 mg/ml (E 321). Advocate spot-on solution for dogs is a clear yellow to brownish solution containing 10 % imidacloprid and 2.5 % moxidectin with benzyl alcohol and Butylhydroxytoluene 1 mg/ml (E 321). The products are presented in a single use plastic tube for cutaneous (spot-on) treatment in cats, ferrets and dogs. Each tube of the small cat and ferret presentations contains 0.4 ml (40 mg imidacloprid, 4 mg moxidectin), the large cat presentation contains 0.8 ml (80 mg imidacloprid, 8 mg moxidectin). Each tube of the dog presentations contains either 0.4 ml (40 mg imidacloprid, 10 mg moxidectin), 1.0 ml (100 mg imidacloprid, 25 mg moxidectin), 2.5 ml (250 mg imidacloprid, 62.5 mg moxidectin) or 4.0 ml (400 mg imidacloprid, 100 mg moxidectin).
For use in cats, ferrets and dogs suffering from, or at risk from, mixed parasitic infections: Cats and Dogs For the treatment and prevention of flea infestation (Ctenocephalides felis), treatment of ear mite infestation (Otodectes cynotis) and prevention of heartworm disease (L3 and L4 larvae of Dirofilaria immitis). The product can be used as part of a treatment strategy for flea allergy dermatitis (FAD). Cats For the treatment of infections with gastrointestinal nematodes (L4 larvae, immature adults and adults of Toxocara cati and Ancylostoma tubaeforme). Ferrets For the treatment and prevention of flea infestation (Ctenocephalides felis) and the prevention of heartworm disease (L3 and L4 larvae of Dirofilaria immitis). Dogs For the treatment of biting lice (Trichodectes canis), sarcoptic mange (caused by Sarcoptes scabiei var. canis), demodicosis (caused by Demodex canis). Treatment of Angiostrongylus vasorum and treatment of infections with gastrointestinal nematodes (L4 larvae, immature adults and adults of Toxocara canis, Ancylostoma caninum, Uncinaria stenocephala and adults of Toxascaris leonina and Trichuris vulpis).
Do not apply directly to the ear canal. Treatment of biting lice (Trichodectes canis) (Dogs) A single dose should be administered. A further veterinary examination 30 days after treatment is recommended as some animals may require a second treatment. Treatment of sarcoptic mange (caused by Sarcoptes scabiei var. canis) (Dogs) A single dose should be administered twice 4 weeks apart. Treatment of demodicosis (caused by Demodex canis) (Dogs) A single dose administered 2 to 4 times at 4 weekly intervals is efficacious against Demodex canis and leads to a marked improvement of clinical signs. As demodicosis is a multi-factorial disease, where possible, it is advisable to also treat any underlying disease appropriately. Heartworm prevention (Cats, Ferrets & Dogs) Cats, ferrets and dogs in areas endemic for heartworm, or those which have travelled to endemic areas, may be infected with adult heartworms. Therefore prior to treatment with Advocate, the advice provided in Contra-Indications and Warnings etc should be considered. For prevention of heartworm disease, the product must be applied at regular monthly intervals during the time of the year when mosquitoes (the intermediate hosts which carry and transmit heartworm larvae) are present. The product may be administered throughout the year or at least 1 month before the first expected exposure to mosquitoes. Treatment should continue at regular monthly intervals until 1 month after the last exposure to mosquitoes. To establish a treatment routine, it is recommended that the same day or date be used each month. When replacing another heartworm preventative product in a heartworm prevention programme, the first treatment with Advocate must be given within 1 month of the last dose of the former medication. In non-endemic areas there should be no risk of animals having heartworm. Therefore they can be treated without special precautions.
Contra-indications, warnings, etc
Do not use in kittens under 9 weeks of age. Do not use in puppies under 7 weeks of age. For ferrets: Do not use Advocate for Large cats (0.8ml) or Advocate for Dogs (any size). Treatment of cats or dogs weighing less than 1 kg, and ferrets weighing less than 0.8 kg should be based on a risk-benefit assessment. Do not use in the case of hypersensitivity to the active substances or to any of the excipients. There is limited experience on the use of the product in sick and debilitated animals, thus the product should only be used based on a risk-benefit assessment for these animals. The product�s efficacy has not been tested in ferrets weighing over 2 kg and therefore the duration of effect might be shorter in these animals. For cats, �Advocate Spot-on Solution for cats�, which contains 10 % imidacloprid and 1.0 % moxidectin, must be used. For ferrets �Advocate Spot-on Solution for small cats and ferrets�, which contains 10 % imidacloprid and 1.0 % moxidectin, must be used. For dogs, the �Advocate Spot-on Solution for dogs�, which contains 10 % imidacloprid and 2.5 % moxidectin, must be used. Use of the product may result in transient pruritus in the animal. On rare occasions greasy fur, erythema and vomiting can occur. These signs disappear without further treatment. The product may, in rare cases cause local hypersensitivity reactions. If the animal licks the application site after treatment, transient neurological signs may be observed infrequently. The product may in very rare cases cause at the application site a sensation resulting in transient behavioural changes such as lethargy, agitation, and inappetence. The product tastes bitter. Salivation may occasionally occur if the animal licks the application site immediately after treatment. This is not a sign of intoxication and disappears within some minutes without treatment. Correct application will minimise licking of the application site. Care should be taken that the contents of the pipette or the applied dose does not come into contact with the eyes or mouth of the recipient and/or other animals. Do not allow recently treated animals to groom each other. When the product is applied in 3 to 4 separate spots in larger dogs, specific care should be taken to prevent the animal licking the application sites. This product contains moxidectin (a macrocyclic lactone), special care should be taken with Collies, Old English Sheepdogs and related breeds or crossbreeds, to correctly administer the product as described above. In particular, oral uptake by the recipient and/or other animals should be prevented. It is recommended that cats and ferrets living in, or travelling to areas endemic for heartworm are treated monthly with the product to protect them from heartworm disease. Whilst the accuracy of diagnosis of heartworm infection is limited, it is recommended that attempts be made to check the heartworm status of any cat and ferret aged over 6 months, before beginning prophylactic treatment, as use of the product on cats or ferrets which have adult heartworms may cause serious adverse effects, including death. If adult heartworm infection is diagnosed, the infection should be treated in accordance with current scientific knowledge. Although the product may be safely administered to dogs infected with adult heartworms, it has no therapeutic effect against adult Dirofilaria immitis. It is therefore recommended that all dogs 6 months of age or more, living in areas endemic for heartworm, should be tested for existing adult heartworm infection before being treated with the product. The safety of the veterinary medicinal product has not been established during pregnancy and lactation. Laboratory studies with either imidacloprid or moxidectin in rats and rabbits have not produced any evidence of teratogenic, foetotoxic or maternotoxic effects. Use only according to the risk-benefit assessment. During treatment with Advocate no other antiparasitic macrocyclic lactone should be administered. No interactions between Advocate and routinely used veterinary medicinal products or medical or surgical procedures have been observed. Up to 10 times the recommended dose was tolerated in adult dogs and cats with no evidence of adverse effects or undesirable clinical signs. The product was administered to kittens and puppies at up to 5 times the recommended dose, every 2 weeks for 6 treatments, and there were no serious safety concerns. Transient mydriasis, salivation, vomiting and transient rapid respiration were observed. The product was administered to ferrets at 5 times the recommended dose, every 2 weeks for 4 treatments, and there was no evidence of adverse effects or undesirable clinical signs. After accidental oral ingestion, transient neurological signs such as ataxia, generalised tremors, ocular signs (dilated pupils, little pupillary reflex, nystagmus), abnormal respiration, salivation and vomiting may occur infrequently. In case of accidental oral uptake, symptomatic treatment should be administered. There is no known specific antidote. The use of activated charcoal may be beneficial. Ivermectin-sensitive Collie dogs tolerated up to 5 times the recommended dose without any adverse effects. However, when 40% of the unit dose was given orally, severe neurological signs were observed. Oral administration of 10% of the recommended dose produced no adverse effects. Dogs infected with adult heartworms tolerated up to 5 times the recommended dose, every 2 weeks for 3 treatments, without any adverse effects. Brief contact of the animal with water on one or two occasions between monthly treatments is unlikely to significantly reduce the efficacy of the product. However, frequent shampooing or immersion of the animal in water after treatment may reduce the efficacy of the product. Parasite resistance to any particular class of anthelmintic may develop following frequent, repeated use of an anthelmintic of that class. The solvent in Advocate may stain certain materials including leather, fabrics, plastics and finished surfaces. Allow the application site to dry before permitting contact with such materials.
Avoid contact with skin, eyes or mouth. Do not eat, drink or smoke during application. Wash hands thoroughly after use. After application do not stroke or groom animals until the application site is dry. In case of accidental spillage onto skin, wash off immediately with soap and water. People with a known hypersensitivity to either benzyl alcohol, imidacloprid or moxidectin should administer the product with caution. In very rare cases the product may cause skin sensitisation or transient skin reactions (for example allergy, irritation or tingling). If the product accidentally gets into eyes, they should be thoroughly flushed with water. If skin or eye symptoms persist, or the product is accidentally swallowed, seek medical attention and show the package insert to the physician. Environmental Safety Any unused product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements. Advocate should not be allowed to enter surface waters as it has harmful effects on aquatic organisms: moxidectin is highly toxic to aquatic organisms. Dogs should not be allowed to swim in surface waters for 4 days after treatment.
Advocate is a POM-V (Pet Prescription Required)