Palladia - 10mg Palladia Tablets for Dogs - Per Tablet
337547
10mg Palladia is a prescription medication used to treat mast cell tumours in dogs. Each tablet contains 10mg of toceranib phosphate, a targeted therapy designed to slow tumour growth and prevent the spread of cancer cells.
Palladia is the first veterinary-approved cancer treatment specifically developed for dogs. It is commonly prescribed for dogs with grade II or III mast cell tumours that have spread or cannot be surgically removed. This medication works by blocking signals that allow tumour cells to grow, helping to manage the progression of the disease.
How 10mg Palladia Works
Palladia contains toceranib phosphate, a tyrosine kinase inhibitor (TKI) that disrupts cancer cell growth. Tyrosine kinases are enzymes that regulate cell division and blood vessel formation. In mast cell tumours, these enzymes can become overactive, leading to uncontrolled tumour growth.
Palladia works by:
- Blocking tyrosine kinase activity, which prevents tumour cells from dividing and multiplying.
- Cutting off the blood supply to the tumour, restricting its ability to grow.
- Targeting cancerous cells while minimising damage to healthy tissue.
By interfering with these cancer growth mechanisms, Palladia helps slow the progression of mast cell tumours and may reduce their size over time. Some dogs experience tumour shrinkage, while others may see slowed disease progression.
VET PRESCRIPTION REQUIRED
Product Features
- Pack Size: - Sold Individually
- Target Animal: - Dog (Canine)
- Related Condition: - Mast cell tumours in dogs
- Pet Prescription Required?: - Yes (For UK Orders)
- Active Ingredient: - Toceranib Phosphate
- Product Name: - 10mg Palladia Tablets for Dogs
More Information
Description
10mg Palladia Tablets for Dogs - Treatment for Mast Cell Tumours in Dogs
Palladia may only be supplied with a valid veterinary prescription issued by your vet. You should only purchase Palladia if you have or are in the process of arranging such a prescription. See information bar for further details.
What are Mast Cell Tumours in Dogs?
Mast cell tumours (MCTs) are one of the most common types of skin cancer in dogs. They develop from mast cells, which are part of the immune system and play a role in allergic responses and inflammation.
Mast cell tumours can appear anywhere on the body, but they are most commonly found on the skin, limbs, or trunk. These tumours can vary in appearance and may be mistaken for harmless lumps or cysts. Some grow slowly, while others become aggressive and spread to other organs.
Mast cell tumours are graded based on their severity:
- Grade I – Tumours are confined to the skin and less likely to spread.
- Grade II – Tumours have unpredictable behaviour and may spread to surrounding tissue.
- Grade III – Highly aggressive tumours with a high risk of metastasis.
Palladia is often prescribed for grade II or III mast cell tumours that have become inoperable or have spread beyond the original tumour site.
Signs of Mast Cell Tumours in Dogs
The symptoms of mast cell tumours can vary depending on the location and severity of the tumour. Common signs include:
- A lump or swelling on the skin, often raised or firm to the touch
- Redness, inflammation, or ulceration of a lump
- Rapid changes in size or shape of a lump
- Itching or irritation around the tumour site
- Gastrointestinal symptoms, such as vomiting or diarrhoea
- Loss of appetite and weight loss in more advanced cases
- Swelling due to histamine release from the tumour, which can cause systemic reactions
Mast cell tumours can cause the release of histamines and other inflammatory chemicals, leading to allergic reactions, stomach ulcers, and swelling. In aggressive cases, the cancer may spread to the lymph nodes, liver, spleen, or bone marrow.
Administering Palladia to Dogs
Palladia is available in 10mg tablets and should be given exactly as prescribed by a veterinarian. The dosage is determined based on the dog’s weight and medical condition.
The tablets should be administered every other day or according to veterinary instructions. They can be given with or without food, but it is recommended to provide them with a meal to reduce the risk of gastrointestinal side effects.
Owners should wear gloves when handling Palladia tablets, as the medication can be harmful to humans. Hands should be washed immediately after administering the tablet.
Regular veterinary monitoring is required to assess the dog’s response to treatment and adjust the dosage if necessary.
Expected Response to Treatment
Palladia does not provide an immediate cure for mast cell tumours but can help slow tumour growth, reduce tumour size, and improve quality of life. Some dogs respond well and experience tumour shrinkage, while others may see stabilisation of tumour progression.
Treatment success varies depending on the severity of the tumour and the individual dog’s response. Regular veterinary check-ups and diagnostic tests, including blood work and imaging, help assess the effectiveness of the medication.
Possible Side Effects of Palladia
Palladia is a powerful medication that can cause side effects, particularly during the early stages of treatment. Common side effects include:
- Vomiting or diarrhoea
- Loss of appetite
- Lethargy or weakness
- Weight loss
- Lameness or muscle pain
- Changes in blood cell counts
Most side effects are mild to moderate and can be managed with supportive care or temporary dose adjustments. However, if a dog experiences severe vomiting, bloody diarrhoea, or extreme weakness, veterinary attention should be sought immediately.
Precautions and Contraindications
Palladia should only be used under veterinary supervision and is not suitable for all dogs. Important precautions include:
- Not suitable for pregnant or lactating dogs – The effects on unborn or nursing puppies have not been fully studied.
- Use with caution in dogs with pre-existing gastrointestinal disease – Dogs prone to stomach ulcers may require additional medication to prevent irritation.
- Monitor dogs with liver or kidney disease – Regular blood tests are needed to assess organ function.
- Avoid contact with broken or crushed tablets – Palladia should be handled carefully, and owners should follow all safety precautions.
Palladia may interact with other medications, including steroids and antihistamines, so veterinarians should be informed of any other treatments the dog is receiving.
Ongoing Management of Canine Mast Cell Tumours
Mast cell tumours require long-term monitoring, even with successful treatment. Veterinary check-ups help track tumour progression and detect any signs of recurrence.
Additional therapies, such as surgery, radiation, or antihistamines, may be used alongside Palladia depending on the tumour’s behaviour and location. Some dogs may benefit from dietary support, immune-boosting supplements, or pain management strategies.
Owners should observe their dog for any changes in tumour size, new lumps, or side effects from medication. Keeping a record of symptoms and medication response can help veterinarians adjust treatment as needed.
Storage and Handling of Palladia
Palladia tablets should be stored in a cool, dry place, away from direct sunlight. They should be kept out of reach of children and other pets. Unused or expired tablets should be disposed of safely according to veterinary or pharmacy guidance.
Legal category
10mg Palladia is a POM-V (Pet Prescription Required)
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