1.25mg Cardisure Tablet - per Tablet

Description

Cardisure 1.25mg contains pimobendan, a medicine used to treat Congestive Heart Failure in dogs caused by valvular insufficiency or dilated cardiomyopathy. Pimobendan strengthens contraction of the heart muscle and relaxes blood vessels, helping the heart move blood through the circulation more effectively. Cardisure 1.25mg is a meat-flavoured tablet containing 1.25mg of the active ingredient, with a score that allows division into two equal halves. It is usually given twice daily, approximately 12 hours apart, on an empty stomach at least one hour before food. By improving pumping and reducing the resistance to blood flow, this treatment can help dogs with heart failure remain more comfortable and maintain a better quality of life as their condition is managed.

The heart works as a muscular pump, with valves keeping blood moving in the correct direction between its chambers. When a valve no longer closes properly, some blood flows backwards during contraction. This leakage, known as valvular insufficiency or regurgitation, reduces efficient forward flow and can eventually raise pressure behind the affected side of the heart. Cardisure 1.25mg is authorised for heart failure associated with mitral or tricuspid valve insufficiency. The mitral valve sits between the left atrium and left ventricle, and its degeneration is a common cause of canine heart disease. As the condition advances, fluid can accumulate in the lungs or elsewhere in the body. Cardisure 1.25mg helps improve the performance of the heart despite the continuing problem with the valve itself.

Dilated cardiomyopathy is another condition for which Cardisure 1.25mg is used when Congestive Heart Failure develops. In this disease, the heart chambers become enlarged and the muscular walls contract less effectively. A weakened pump may struggle to move enough blood forward, while pressure builds up behind it. Dogs can become less willing to exercise, tire more quickly or develop breathing difficulties as congestion increases. Some also develop an irregular heartbeat. Cardisure 1.25mg improves the force of contraction through an effect called calcium sensitisation, which makes the heart’s contractile proteins respond more effectively to calcium already present in the cells. This action helps the weakened heart generate a stronger contraction without relying solely on a large increase in intracellular calcium.

Pimobendan in Cardisure 1.25mg also inhibits an enzyme called phosphodiesterase III. This contributes to relaxation of blood vessel walls, allowing blood to pass through the circulation with less resistance. A medicine combining improved contraction with vessel relaxation is known as an inodilator. These two actions reduce the effort needed to circulate blood and can improve the amount pumped forward with each heartbeat. Cardisure 1.25mg is frequently used alongside a diuretic when heart failure has caused fluid retention. The diuretic increases removal of sodium and water through the kidneys, while pimobendan improves cardiac performance. Studies in dogs with congestive heart failure due to valve disease have shown benefits for quality of life and life expectancy when pimobendan is used with appropriate accompanying treatment.

Food reduces the absorption of pimobendan, so Cardisure 1.25mg is given on an empty stomach, at least one hour before feeding. The total daily amount is normally divided between morning and evening administrations. Its natural meat flavour can improve acceptance, although individual dogs vary in how readily they take tablets. Each half of Cardisure 1.25mg contains 0.625mg pimobendan, allowing smaller increments when the treatment amount is selected by bodyweight. A divided portion should be returned to its blister and used within three days. The medicine treats established congestive heart failure under its current authorisation; the presence of a heart murmur alone does not establish that a dog has reached this stage. Fluid within the lungs can make breathing faster even during sleep, while congestion affecting the right side of the circulation can lead to abdominal fluid accumulation. These changes reflect increased pressure in different parts of the circulation and can develop alongside reduced exercise tolerance.

Cardisure 1.25mg may occasionally cause an increased heart rate or digestive effects such as vomiting and diarrhoea. Reduced appetite and lethargy are also reported. It must not be used for hypertrophic cardiomyopathy or conditions where an anatomical obstruction, such as aortic stenosis, prevents an increase in cardiac output. Significant liver impairment requires particular care because pimobendan is metabolised in the liver. Cardisure 1.25mg does not remove fluid from the lungs immediately, and severe or rapidly worsening breathing difficulty is an emergency even in a dog already receiving heart medicine. Between treatments, keep tablets below 30°C in their original packaging. Flavoured medicines should be stored securely, since a dog may readily eat more than the intended amount if it gains access to the supply.

What is Cardisure 1.25mg used for in dogs?

Cardisure 1.25mg treats congestive heart failure caused by valvular insufficiency or dilated cardiomyopathy. It contains pimobendan, which strengthens heart muscle contraction and relaxes blood vessels. These actions improve the heart’s ability to circulate blood and can help affected dogs maintain better comfort and quality of life.

How does pimobendan in Cardisure work?

Pimobendan increases the sensitivity of heart muscle proteins to calcium, helping the heart contract more strongly. It also inhibits phosphodiesterase III, contributing to blood vessel relaxation. The combined effect, called inodilation, improves pumping while reducing the resistance against which the heart must move blood.

Can Cardisure 1.25mg tablets be divided?

Yes. The 1.25mg tablet divides into two equal halves, each containing 0.625mg pimobendan. This strength is not authorised for division into equal quarters. Return an unused half to its blister and use it within three days, keeping the remaining tablets below 30°C in their original packaging.

Should Cardisure be given before or after food?

Give Cardisure on an empty stomach at least one hour before food. Food reduces the absorption of pimobendan, so timing around meals affects how the medicine is taken up. The usual daily amount is divided into morning and evening administrations approximately 12 hours apart.

Is Cardisure 1.25mg flavoured?

Yes. Cardisure contains a natural meat flavour, which can help some dogs accept the tablet more readily. The authorised pharmaceutical form is a flavoured tablet. It should be kept securely out of reach because the flavour may encourage a dog to eat more tablets than intended.

Is Cardisure used once or twice a day?

The usual schedule is twice daily, with the total daily amount divided between two administrations approximately 12 hours apart. Each administration is given before food. The number of tablets or halves required depends on the dog’s bodyweight and the selected total daily amount of pimobendan.

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