- New
Trilocur 25ml Oral Suspension for Dogs
963252
25ml Trilocur for Dogs (trilostane oral suspension) is a prescription-only medicine used to help manage hyperadrenocorticism, commonly called Cushing’s disease. It is intended for dogs diagnosed by a veterinary surgeon and supplied as an oral liquid that can be measured accurately to match the prescribed dose.
Trilocur contains trilostane. 25ml Trilocur reduces the production of steroid hormones made by the adrenal glands, particularly cortisol. In dogs with Cushing’s disease, cortisol levels are higher than the body needs. Excess cortisol disrupts normal metabolism and immune function and can affect many organs over time. By lowering cortisol production, trilostane can help control clinical signs and improve day-to-day comfort.
How Trilocur works
The adrenal glands sit close to the kidneys and produce several important hormones, including cortisol. Cortisol helps the body respond to stress, regulates the use of fat, protein and carbohydrates, supports blood pressure, and influences the immune system. In Cushing’s disease, cortisol is produced in excess, either because the pituitary gland is stimulating the adrenals too strongly or because an adrenal tumour is producing hormones directly.
Trilocur blocks an enzyme involved in the adrenal gland’s steroid production pathway (3β-hydroxysteroid dehydrogenase). This reduces the synthesis of cortisol and related adrenal steroids. The aim of treatment is not to remove cortisol completely, but to bring production back into a controlled range. Because dogs respond differently, dosing and monitoring are important, especially early on and after any dose changes.
Trilocur may be prescribed for:
- Pituitary-dependent hyperadrenocorticism (the most common form), where a pituitary change increases ACTH stimulation of the adrenal glands.
- Adrenal-dependent hyperadrenocorticism, where an adrenal tumour produces excess hormones.
More Information
Description
Trilocur 25ml is given by mouth as directed by your vet. It is often administered with food to support consistent absorption. As an oral suspension, it should be measured carefully using the dosing device provided. You should not change the dose or dosing frequency unless your vet instructs you to do so.
Regular veterinary monitoring is part of safe treatment. Your vet may assess clinical signs and use blood tests, which can include an ACTH stimulation test, routine biochemistry and electrolyte checks. Monitoring helps confirm that cortisol is being controlled without suppressing it too far.
As cortisol levels come under control, many owners first notice changes in drinking, urination and appetite. Panting and restlessness may reduce, and some dogs become more willing to exercise. Skin and coat recovery is usually slower, because hair growth cycles take time and secondary infections may need separate treatment. Your vet may treat concurrent problems such as urinary tract infection, dermatitis or high blood pressure alongside trilostane.
Trilostane’s effect is linked to dosing routine. Giving the medicine at a similar time each day and in the same way (for example, always with food) helps your vet interpret follow-up tests and decide whether any adjustment is needed. If your dog’s routine changes, if you switch diets, or if you start new medicines, let your vet know so monitoring can be tailored appropriately.
Many dogs tolerate trilostane well when appropriately monitored, but side effects can occur. Reduced appetite, vomiting, diarrhoea or lethargy may be seen. In some cases, trilostane can suppress adrenal function too strongly, leading to low cortisol (hypoadrenocorticism) or a temporary reduction in adrenal activity. This can become serious and may require urgent veterinary attention.
What is hyperadrenocorticism (Cushing’s disease) in dogs
Hyperadrenocorticism is a hormonal disorder where the body is exposed to persistently high cortisol. It most commonly affects middle-aged to older dogs and tends to develop gradually. Because the early signs can look like normal ageing, it may be missed until symptoms become more obvious.
There are two main naturally occurring forms:
Pituitary-dependent Cushing’s disease (PDH): The pituitary gland releases too much ACTH, which tells the adrenal glands to produce excess cortisol.
Adrenal-dependent Cushing’s disease (ADH): A tumour in one adrenal gland produces cortisol directly.
A third form, iatrogenic Cushing’s disease, can occur after prolonged steroid medication. Management differs and should be guided by a vet.
- Cushing’s disease can affect nearly every body system. Signs may include:
- Increased thirst and increased urination.
- Increased appetite and weight gain.
- A pot-bellied appearance due to muscle weakness and fat redistribution.
- Panting, reduced exercise tolerance and tiredness.
- Thinning coat, hair loss, recurrent skin infections, or slow hair regrowth after clipping.
- Fragile skin, bruising or poor wound healing.
- Recurrent urinary tract infections.
Some dogs also develop complications such as high blood pressure, protein loss through the kidneys, diabetes mellitus, or an increased tendency to form blood clots. Your vet may screen for these issues as part of diagnosis and follow-up.
Diagnosis usually involves a combination of history, physical examination and laboratory testing. Routine blood work may suggest the condition, but specific endocrine tests are typically needed to confirm it. Imaging may also be recommended to assess the adrenal glands and help guide the treatment plan.
Cushing’s disease is usually managed long term. Improvements in thirst, urination and appetite may be noticed within days to weeks, while skin and coat changes often take longer. Ongoing check-ups help keep control stable and allow your vet to adjust treatment if your dog’s needs change.
What is Cushing’s disease in dogs?
Cushing’s disease (hyperadrenocorticism) is a hormonal disorder where a dog’s body is exposed to too much cortisol over time. Cortisol is important for normal stress response and metabolism, but persistently high levels can lead to increased thirst and urination, increased appetite, panting, muscle weakness, and skin or coat changes.
How soon will I see improvement after starting Trilocur?
Some dogs show improvement in thirst, urination and appetite within the first week or two, although response varies. Changes in panting and energy may follow. Skin and coat recovery often takes longer, because hair growth cycles are slow and secondary infections may need separate treatment. Regular rechecks help confirm progress is safe.
Do I need regular blood tests while my dog is on Trilocur?
Yes. Trilostane treatment is usually paired with routine monitoring to make sure cortisol is controlled without being suppressed too far. Your vet may recommend an ACTH stimulation test and standard blood work, including electrolyte checks. Monitoring is especially important after starting treatment, after dose changes, and if your dog becomes unwell.
What should I do if I miss a dose of Trilocur?
If you miss a dose, follow the advice your vet has provided for your dog’s treatment plan. In many cases, a missed dose is given when remembered if it is close to the usual time, but a double dose should not be given. If you are unsure, contact your vet for clear guidance.
Is Trilocur a cure for Cushing’s disease?
Trilocur does not cure the underlying cause of Cushing’s disease in most dogs. It is used to control hormone production and reduce clinical signs. Many dogs remain on treatment long term, with periodic dose adjustments based on symptoms and test results. Your vet will tailor the plan to your dog’s form of disease.
You may also like
Vetoryl 10mg Capsule for Dogs - per Capsule
10mg Vetoryl Capsules are used in the treatment of Cushing's syndrome in dogs. Vetoryl may be used for treatment of both pituitary-dependent and adrenal-dependent hyperadrenocorticism in dogs.
Cushing's disease, also known as hyperadrenocorticism, is a condition that affects dogs, causing an overproduction of the cortisol hormone. This overproduction can lead to a range of symptoms, including increased thirst, frequent urination, hair loss, and a pot-bellied appearance. 10mg Vetoryl for Dogs is a prescription-only medication used to manage this condition.
Cushing's disease is most commonly diagnosed in older dogs. The condition arises when there's an excess of cortisol, a hormone produced in response to stress. This hormone plays a crucial role in what we term the 'fight or flight' response. However, when produced in excessive amounts, it can lead to symptoms such as panting, lethargy, hair loss, and hypertension. These symptoms can fluctuate daily, making it essential to find a consistent treatment.
Vetoryl 10mg for Dogs contains an active ingredient called Trilostane. Trilostane works by blocking the excessive production of cortisol in the body. By doing so, it reduces the symptoms of Cushing's disease, bringing them to a more comfortable level for your pet. Over time, with the consistent use of 10mg Vetoryl Capsules, the skin becomes more elastic, the coat regains its lustre, and excessive thirst and hunger diminish. Moreover, bladder control improves, enhancing the overall quality of life for your pet.
VET PRESCRIPTION REQUIRED
Vetoryl 120mg Capsule for Dogs - per Capsule
120mg Vetoryl Capsules are used in the treatment of Cushing's syndrome in dogs. Vetoryl may be used for treatment of both pituitary-dependent and adrenal-dependent hyperadrenocorticism in dogs. VET PRESCRIPTION REQUIRED
Vetoryl 30mg Capsule for Dogs - per Capsule
30mg Vetoryl Capsules are used in the treatment of Cushing's syndrome in dogs. Vetoryl may be used for treatment of both pituitary-dependent and adrenal-dependent hyperadrenocorticism in dogs. VET PRESCRIPTION REQUIRED
10mg Trilotab Chewable Tablets for Dogs - Pack of 30
Trilotab 10mg Chewable Tablets for Dogs: Managing Canine Cushing’s Syndrome
10mg Trilotab contains trilostane, an active substance that inhibits the enzyme 3β-hydroxysteroid dehydrogenase. This inhibition reduces cortisol synthesis in the adrenal glands, thereby decreasing excessive cortisol levels in dogs with Cushing’s syndrome.
Administered orally, 10mg Trilotab is designed as a chewable, flavoured tablet to facilitate ease of administration. The tablet features a cross-shaped break line, allowing it to be divided into two or four equal parts to achieve precise dosing tailored to the dog's weight and specific needs.
VETERINARY PRESCRIPTION REQUIRED
30mg Trilotab Chewable Tablets for Dogs - Pack of 30
Trilotab 30mg Chewable Tablets for Dogs: Managing Canine Cushing’s Syndrome
30mg Trilotab contains trilostane, an active substance that inhibits the enzyme 3β-hydroxysteroid dehydrogenase. This inhibition reduces cortisol synthesis in the adrenal glands, thereby decreasing excessive cortisol levels in dogs with Cushing’s syndrome.
Administered orally, 30mg Trilotab is designed as a chewable, flavoured tablet to facilitate ease of administration. The tablet features a cross-shaped break line, allowing it to be divided into two or four equal parts to achieve precise dosing tailored to the dog's weight and specific needs.
VETERINARY PRESCRIPTION REQUIRED
60mg Trilotab Chewable Tablets for Dogs - Pack of 30
Trilotab 60mg Chewable Tablets for Dogs: Managing Canine Cushing’s Syndrome
60mg Trilotab contains trilostane, an active substance that inhibits the enzyme 3β-hydroxysteroid dehydrogenase. This inhibition reduces cortisol synthesis in the adrenal glands, thereby decreasing excessive cortisol levels in dogs with Cushing’s syndrome.
Administered orally, 60mg Trilotab is designed as a chewable, flavoured tablet to facilitate ease of administration. The tablet features a cross-shaped break line, allowing it to be divided into two or four equal parts to achieve precise dosing tailored to the dog's weight and specific needs.
VETERINARY PRESCRIPTION REQUIRED
20mg Vetoryl Tablets for Dogs - Pack of 30
Vetoryl 20mg Tablets are a prescription-only veterinary medicine used in the treatment of Cushing’s disease (also known as hyperadrenocorticism) in dogs.
Each Vetoryl 20mg Flavoured Tablet contains 20mg of trilostane, an active ingredient that helps regulate excessive hormone production in affected dogs. Vetoryl Tablets are designed to be given once daily with food and can be split in half for accurate dosing in dogs requiring smaller amounts.
Cushing’s disease is a common endocrine disorder in middle-aged and older dogs. It occurs when the adrenal glands produce too much cortisol, a steroid hormone that plays a role in stress response, immune function, and metabolism. While cortisol is essential in small amounts, overproduction leads to a range of symptoms that can reduce a dog’s quality of life. These symptoms often develop slowly, making the condition challenging to detect early.
VETERINARY PRESCRIPTION REQUIRED
Trilocur 50ml Oral Suspension for Dogs
Trilocur 50ml Oral Suspension for Dogs is a veterinary medicine used to manage hyperadrenocorticism, often called Cushing’s disease, in dogs. With this condition the body produces too much cortisol for months or years, and the effects can build up gradually. Many owners first notice that their dog drinks far more than normal and needs to urinate more often, including asking to go outside at night or having accidents in the house. Increased appetite, weight gain around the abdomen, heavier panting, and reduced stamina are also common. Some dogs develop thinning hair, fragile skin, or recurrent ear and skin problems, while others seem less interested in exercise or play. Because these signs can overlap with other illnesses, your vet will usually confirm hyperadrenocorticism with a combination of history, examination and laboratory tests before starting Trilocur. Some dogs seem restless and pace, while others become quieter and less keen to exercise. Skin and coat changes can develop over time, including thinning hair, recurrent skin infections, slow hair regrowth after clipping, and fragile skin that bruises easily. Because these signs can overlap with other illnesses, diagnosis and treatment decisions should always be made by a vet, and Trilocur should only be used under veterinary direction.
Trilocur contains trilostane, a medicine that reduces cortisol production within the adrenal glands. Trilostane works by blocking an enzyme involved in making steroid hormones, so the adrenal glands produce less cortisol and release less into the bloodstream. The effect is reversible, which is helpful because your vet can adjust the dose if cortisol control is not adequate or if the effect becomes too strong. Trilocur does not remove the underlying cause of Cushing’s disease, but by lowering cortisol it can reduce the impact of the disease and help a dog feel more comfortable day to day. When Trilocur is working well, owners often notice steadier drinking and urination patterns, less panting, and an improved level of energy. Coat and skin improvements can take longer and tend to be more gradual. The goal is stable control over time, rather than rapid change in a few days.
- New